![Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41467-021-25867-y/MediaObjects/41467_2021_25867_Fig5_HTML.png)
Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications
![Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41467-021-25867-y/MediaObjects/41467_2021_25867_Fig1_HTML.png)
Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications
![Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide | PNAS Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide | PNAS](https://www.pnas.org/cms/10.1073/pnas.1203636109/asset/82f682c4-14bd-42d3-b9a3-b6535e835c99/assets/graphic/pnas.1203636109fig01.jpeg)
Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide | PNAS
![Effect of niacin supplementation on nausea-like behaviour in an isoniazid-induced mouse model of pellagra | British Journal of Nutrition | Cambridge Core Effect of niacin supplementation on nausea-like behaviour in an isoniazid-induced mouse model of pellagra | British Journal of Nutrition | Cambridge Core](https://static.cambridge.org/binary/version/id/urn:cambridge.org:id:binary:20220314151245622-0092:S0007114521001835:S0007114521001835_fig1.png?pub-status=live)
Effect of niacin supplementation on nausea-like behaviour in an isoniazid-induced mouse model of pellagra | British Journal of Nutrition | Cambridge Core
![Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats | Chemical Research in Toxicology Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats | Chemical Research in Toxicology](https://pubs.acs.org/cms/10.1021/tx300341r/asset/images/large/tx-2012-00341r_0003.jpeg)
Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats | Chemical Research in Toxicology
![Xanthohumol from Humulus lupulus L. potentiates the killing of Mycobacterium tuberculosis and mitigates liver toxicity by the combination of isoniazid ... - RSC Advances (RSC Publishing) DOI:10.1039/C9RA10347C Xanthohumol from Humulus lupulus L. potentiates the killing of Mycobacterium tuberculosis and mitigates liver toxicity by the combination of isoniazid ... - RSC Advances (RSC Publishing) DOI:10.1039/C9RA10347C](https://pubs.rsc.org/image/article/2020/RA/c9ra10347c/c9ra10347c-f4_hi-res.gif)
Xanthohumol from Humulus lupulus L. potentiates the killing of Mycobacterium tuberculosis and mitigates liver toxicity by the combination of isoniazid ... - RSC Advances (RSC Publishing) DOI:10.1039/C9RA10347C
![Xanthohumol from Humulus lupulus L. potentiates the killing of Mycobacterium tuberculosis and mitigates liver toxicity by the combination of isoniazid ... - RSC Advances (RSC Publishing) DOI:10.1039/C9RA10347C Xanthohumol from Humulus lupulus L. potentiates the killing of Mycobacterium tuberculosis and mitigates liver toxicity by the combination of isoniazid ... - RSC Advances (RSC Publishing) DOI:10.1039/C9RA10347C](https://pubs.rsc.org/image/article/2020/RA/c9ra10347c/c9ra10347c-f5_hi-res.gif)
Xanthohumol from Humulus lupulus L. potentiates the killing of Mycobacterium tuberculosis and mitigates liver toxicity by the combination of isoniazid ... - RSC Advances (RSC Publishing) DOI:10.1039/C9RA10347C
![JCI Insight - Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis JCI Insight - Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis](https://df6sxcketz7bb.cloudfront.net/manuscripts/92000/92973/medium/jci.insight.92973.f2.jpg)
JCI Insight - Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis
![NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans | Scientific Reports NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans | Scientific Reports](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-017-09177-2/MediaObjects/41598_2017_9177_Fig1_HTML.jpg)
NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans | Scientific Reports
Epidemiology in History Ficacy, Effectiveness, Toxicity, Durability, and Duration | PDF | Tuberculosis | Hiv/Aids
![Assessing whether isoniazid is essential during the first 14 days of tuberculosis therapy: a phase 2a, open-label, randomised controlled trial - ScienceDirect Assessing whether isoniazid is essential during the first 14 days of tuberculosis therapy: a phase 2a, open-label, randomised controlled trial - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2666524720300112-gr1.gif)
Assessing whether isoniazid is essential during the first 14 days of tuberculosis therapy: a phase 2a, open-label, randomised controlled trial - ScienceDirect
![Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide | PNAS Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide | PNAS](https://www.pnas.org/cms/10.1073/pnas.1203636109/asset/d72661ca-0612-42ec-aa83-23fdb633060e/assets/graphic/pnas.1203636109fig02.jpeg)
Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide | PNAS
![A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis | Nature Communications A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis | Nature Communications](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-022-32043-3/MediaObjects/41467_2022_32043_Fig1_HTML.png)
A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis | Nature Communications
![Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model | Antimicrobial Agents and Chemotherapy Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model | Antimicrobial Agents and Chemotherapy](https://journals.asm.org/cms/10.1128/aac.02071-18/asset/9dd07be9-e726-4adb-a263-b8358a8e1a2b/assets/graphic/aac.02071-18-f0002.jpeg)
Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model | Antimicrobial Agents and Chemotherapy
![A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy | Antimicrobial Agents and Chemotherapy A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy | Antimicrobial Agents and Chemotherapy](https://journals.asm.org/cms/10.1128/aac.00508-16/asset/1fc77877-e127-4c40-ab99-afb5f47e37db/assets/graphic/zac0101655850003.jpeg)
A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy | Antimicrobial Agents and Chemotherapy
![A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy | Antimicrobial Agents and Chemotherapy A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy | Antimicrobial Agents and Chemotherapy](https://journals.asm.org/cms/10.1128/aac.00508-16/asset/60bdcfa3-d0e0-477f-b6a1-f8d2b1327b2d/assets/graphic/zac0101655850001.jpeg)
A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy | Antimicrobial Agents and Chemotherapy
![Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats | Chemical Research in Toxicology Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats | Chemical Research in Toxicology](https://pubs.acs.org/cms/10.1021/tx300341r/asset/images/medium/tx-2012-00341r_0010.gif)
Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats | Chemical Research in Toxicology
![Effect of niacin supplementation on nausea-like behaviour in an isoniazid-induced mouse model of pellagra | British Journal of Nutrition | Cambridge Core Effect of niacin supplementation on nausea-like behaviour in an isoniazid-induced mouse model of pellagra | British Journal of Nutrition | Cambridge Core](https://static.cambridge.org/binary/version/id/urn:cambridge.org:id:binary:20220314151245622-0092:S0007114521001835:S0007114521001835_fig3.png?pub-status=live)
Effect of niacin supplementation on nausea-like behaviour in an isoniazid-induced mouse model of pellagra | British Journal of Nutrition | Cambridge Core
![Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41467-021-25867-y/MediaObjects/41467_2021_25867_Fig6_HTML.png)
Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications
![Assessing whether isoniazid is essential during the first 14 days of tuberculosis therapy: a phase 2a, open-label, randomised controlled trial - ScienceDirect Assessing whether isoniazid is essential during the first 14 days of tuberculosis therapy: a phase 2a, open-label, randomised controlled trial - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2666524720300112-gr2.jpg)
Assessing whether isoniazid is essential during the first 14 days of tuberculosis therapy: a phase 2a, open-label, randomised controlled trial - ScienceDirect
![Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41467-021-25867-y/MediaObjects/41467_2021_25867_Fig2_HTML.png)
Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid | Nature Communications
![Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model | Antimicrobial Agents and Chemotherapy Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model | Antimicrobial Agents and Chemotherapy](https://journals.asm.org/cms/10.1128/aac.02071-18/asset/7be3e562-6524-46a7-a73f-66cc8bb01050/assets/graphic/aac.02071-18-f0003.jpeg)
Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model | Antimicrobial Agents and Chemotherapy
![Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice | PNAS Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice | PNAS](https://www.pnas.org/cms/10.1073/pnas.1003219107/asset/6eeea29a-8587-4085-ab6b-c9f67e87a2f2/assets/graphic/pnas.1003219107fig02.jpeg)